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The CH25H-CYP7B1-ROR alpha axis of cholesterol metabolism regulates osteoarthritis

Our baseline health evaluation is extremely comprehensive, says Katherine Saunders, MD, an obesity medicine specialist with FlyteHealth and Weill Cornell Medicine in New York City

A large real-world cohort study published in JAMA Network Open also showed why continuity matters: among adults with overweight or obesity starting GLP-1 receptor agonists, discontinuation within one year was common, especially among patients without type 2 diabetes [JAMA Network Open, 2025]

doi: 10.1007/s00125-006-0237-0 139 BoeyDLinSEnriquezRFLeeNJSlackKCouzensMet al

At the same time, side effects like nausea and vomiting are common, which may limit tolerance for some patients