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In the bulk of genomic DNA, most CpG sites are heavily methylated while CpG islands (sites of CpG clusters) in germ-line tissues and located near promoters of normal somatic cells, remain unmethylated, thus allowing gene expression to occur

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Adam Martin returns to the podcast

Females with factors that affect female fertility such as endometriosis, diabetes, hypercortisolism, and factors related to serious diseases that could affect continuous pregnancy were excluded in this study