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Voice rest serves to reverse swelling associated with phonotrauma and can help restore baseline voice, but hoarseness will recur the next time the voice is used strenuously unless underlying patterns of voice use change

[24] In one study, fullthickness wounds of 6 millimeters in diameter were created in an ischemic skin flap on the backs of rats, and for 13 days the wound sites were then treated daily with topical GHK-Cu or topical hydroxypropyl methylcellulose vehicle, or given no treatment

It is naturally produced in the body, but its level gets depleted with age and environmental stressors

& Zhao, N

The effective GHK-Cu half life is extended locally, not systemically