356,357 The activated AMPK pathway can upregulate the expression of FTH1 and GPX4 in intestinal tissues and can improve iron metabolism and redox disorders in the colons of UC rats, thereby effectively treating UC
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Simultaneously, Deacon et al (72) demonstrated cleavage of GLP-1 [736] amide to GLP-1 [936] amide in human plasma in vitro, with these actions sensitive to the DPP4 inhibitor diprotin A, findings consistent with those reported by Pauly et al (140) analyzing the degradation of GIP and GLP-1 by human serum in vitro