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Weight loss in these patients may reduce caloric demands, potentially lowering TSH and requiring downward dose adjustment of thyroid medication

This panel measures key biomarkers of oxidative injury, including 8-OHdG, lipid peroxides, and dityrosine , that reflect the ongoing oxidative burden

Correlating the global signal with the time series of each voxel (Pearsons correlation) yields a whole-brain correlation, which is also considered a weighted form of functional connectivity density [42]

This is not surprising, considering that tirzepatide and semaglutide evoked more pronounced TBWL and also have glucose-lowering effects by slowing gastric emptying, stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner, independent of their effects on body weight 50,51

Patients with higher starting weights and greater insulin resistance often experience faster initial weight reduction than those closer to their goal weight