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The major pathways involved are insulin signaling defects, AGE-RAGE axis activation, PI3K/AKT/FOXO1 dysregulation, JNK pathway stimulation, and Peroxisome proliferator-activated receptor gamma (PPAR) dysfunction [60]

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Role of PARL-PINK1-Parkin pathway in adipocyte differentiation

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Fat accumulation in the liver or nonalcoholic fatty liver disease (NAFLD) is strongly related with several metabolic disorders, in particular low HDL cholesterol and high triglycerides, present in patients with type 2 diabetes