In addition to having a detrimental effect on patient comfort and quality of life, these cutaneous side effects frequently impede treatment compliance, resulting in dose reduction or discontinuation [3]

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MY: Writing original draft
In the morning, each participant filled out a Hangover Symptom Scale questionnaire, evaluating each hangover symptom (feeling thirsty or dehydrated, feeling more tired than usual, headache, nauseated, vomited, feeling weak, difficulty concentrating, more sensitive to light and sound than usual, sweating more than usual, had trouble sleeping, feeling anxious, feeling depressed, experienced trembling or shaking) on a 5 point Likert scale with 1 representing Strongly Disagree and 5 representing Strongly Agree
(PubMed) Ashor AW, Lara J, Mathers JC, Siervo M