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rarely, it is associated with dyspnea or dysphagia from pressure on structures in the neck, or with mild pain and tenderness

However, important advances have been made recently in the study of the pathophysiological consequences of supplementation in animal models, which can serve as a precedent and basis for future studies in humans which could finally clarify the utility of this relevant antioxidant in clinical medicine

Reproduction studies of acetylcysteine solution with isoproterenol have been performed in rats and of acetylcysteine solution alone in rabbits at doses up to 2.6 times the human dose

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We postulate that ER signaling confers ferroptosis resistance by transcriptionally upregulating antioxidant defenses such as glutathione peroxidase 4 (GPX4), a mechanism recently validated in other epithelial models [35]