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Fc fusion to glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human GLP-1 receptor activation

Furthermore, IL-12 is thought to promote DPP-4 translation, whereas TNF- is thought to decrease its expression [34, 35]

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Although promising, these anti-metastatic effects have so far been observed predominantly in preclinical settings, and no large-scale clinical trials have confirmed the protective role of canakinumab in human skeletal metastasis

Support networks, including family, friends, and healthcare providers, play a critical role