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The latter option, that loss of oxidants can augment apoptosis, is supported by findings that correlate increased cellular hydrogen peroxide levels with resistance to apoptotic signaling in some cell systems (18, 86), as catalase overexpression in either cytoplasmic or mitochondrial compartments potentiated apoptosis, whereas inhibiting endogenous catalase promoted cell survival

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Pregnant women are advised to ensure adequate folate intake to promote neural tube development, which occurs in the early stages of pregnancy

35 Therefore, it is worth exploring other sites of ROS production in mitochondria