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In particular, the observed changes in MAPK- and Rap1-related pathways are biologically plausible, given their established roles in inflammatory signaling and epithelial junction regulation, respectively [59, 71, 72]

22 , 23 In a series of publications, the Truscott laboratory has identified a number of kynurenines and derivatives that are present in the human lens, they have described the pathways whereby these compounds are produced, and they have shown that these UV filters absorb ultraviolet radiation that otherwise could have detrimental photochemical effects on the lens and retina

Sinomenine inhibits the inflammatory responses of human fibroblast-like synoviocytes via the TLR4/MyD88/NF-kappaB signaling pathway in rheumatoid arthritis