The reason for the lower price: Eli Lilly is cutting out the middlemen (such as telehealth companies and concierge docs), who add hefty markups, and will be selling the drug in vials, rather than the costlier, trickier-to-manufacture preloaded pen form (also known as an autoinjector)
Some studies have reported GLP-1R expression identified through immunohistochemistry in human liver tissue or liver cell lines, 43,44 but RNA sequencing has not detected GLP-1R in human liver tissue, including the non-parenchymal Kupffer or stellate cells
The company is confident in its ability to capture value
This is additive with antihypertensive medications
Though only currently indicated for diabetes, the combined HbA1c and weight loss benefits make Mounjaro a standout in the class, creating a level of demand that has significantly grown the size of the overall GLP-1 market