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The Harding lab animal studies used various doses, often extrapolated by community members using simple body weight scaling
Another limitation worth noting: several experiments used only males, which probably limits our insights into sex-specific mechanisms
Ther Drug Monit 30(3):32032
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The simplest way to think about them is in two buckets: stomach symptoms during dose escalation, and a separate skin-sensation signal at the highest dose in Phase 3
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