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Overlapping conditions and diagnosis: Many other conditions have mast cell activation as a component, including idiopathic abdominal pain, GERD (heartburn), chronic urticaria, fibromyalgia, atypical drug and insect bite reactions, allergies, chronic sinusitis, pharyngitis and vocal tension, dermatographism, chronic headaches, interstitial cystitis, and atrial fibrillation.[ref] Additionally, some researchers point out the growing evidence of mast cell involvement in several different autoimmune diseases, including MS, type 1 diabetes, and rheumatoid arthritis.[ref] Lets dig into some of these in more depth, exploring how they relate to mast cell activation

When the usual explanations have been ruled out, and the pattern continues, vitamin B12 deficiency in dogs is something worth discussing with your vet

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Kozlowski K, Sutcliffe J, Barylak A, Harrington G, Kemperdick H, Nolte K, et al