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As patients with both obesity and T2DM have dysregulated skeletal muscle glucose uptake and glycogen metabolism compared to individuals with obesity alone, further research should identify and determine if there are differences in losses of skeletal muscle mass among these groups following GLP-1RA treatment

This approach allowed us to explore broad themes such as the effects of GLP-1 RAs on osteoblast and osteoclast activity, bone formation and resorption, and the overall impact on bone integrity and healing

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The potential of GLP-1R agonists as multi-faceted therapeutic agents extends their benefits to various pain conditions, including inflammatory, neuropathic, visceral pain, and headaches (Table 3)