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D27 is described as an iron-containing enzyme in the chloroplast that participates in the isomerization of carotenoids, including the conversion of all-trans--carotene to 9-cis--carotene, which is essential for subsequent CCD7 and CCD8 mediated reactions in SL biosynthesis 156

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Hence, an interesting question that remains unaddressed is whether inhibitors of necroptosis molecules attenuate CP-induced AKI by controlling lysosomal biogenesis and autophagic flux through TFEB

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