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Guirguis says combination treatments such as this could offer additive or synergistic effects meaning that patients have a better chance of responding to at least one of the mechanisms and could experience fewer GI side effects as a result of the dual approach

not available for commercial use in U.S.), dulaglutide (Trulicity, Eli Lilly), oral semaglutide (Rybelsus, Novo Nordisk) and efpeglenatide (Sanofi) researchers also found that human and exendin-based GLP-1 receptor agonists reduce risk for all-cause mortality, hospitalization for heart failure, and a composite kidney outcome of development of new-onset macroalbuminuria, decline in estimated glomerular filtration rate or increase in creatinine, renal replacement therapy or renal death

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