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Recent targeted therapies are focusing on molecular pathways implicated in OA progression, including TGF-/ALK5 signaling, Wnt/-catenin modulation, NF-B suppression, and ferroptosis inhibition (Tian et al., 2025

For technical claims, the article relies on neutral analytical and documentation sources

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doi: 10.1038/nm.2415

Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance