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These inhibitors, by increasing the half-life of GLP-1, increase insulin synthesis and secretion, as well as reducing glucagon secretion by pancreatic alpha cells

This results in the accumulation of cytosolic Ca 2+ followed by activation of synaptic vesicle exocytosis, and release of neurotransmitters

While colonoscopy and fecal-based tests remain highly effective, global colorectal cancer incidence continues to rise, with a particularly concerning increase among younger adults

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