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, Christie, I

10.1056/NEJMoa1901118 [DOI] [PubMed] [Google Scholar] 33

Moreover, over the past decade, numerous studies have demonstrated the critical roles of ERAD in the development of neurodegenerative diseases

[2] It has also been associated with higher rates of Down syndrome and birth defects in offspring of those with the MTHFR gene variation, as well as other issues that may manifest later on in life, such as an increased risk of blood clots and a higher risk of certain cancers