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Biochemistry 35 , 44454456, doi: 10.1021/bi9521093 (1996)

When the eruption became increasingly symptomatic with burning, itching and scaling, two punch biopsies were taken from the left lateral inferior eyelid and left zygoma (figure 1) that clarified the diagnosis as amelanotic malignant melanoma in situ, lentigo maligna type (MISLMA)

Additionally, a maintenance dose may be necessary in the long term