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Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1

Murugadoss, K., Varma, G., Venkatakrishnan, A

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Local viral delivery of the IGF-I isoforms promoted muscle hypertrophy in young mice, and the effect was isoform- and age-dependent: in growing animals both IGF-IA and IGF-IB enlarged muscle, whereas in older (six-month) animals only IGF-IA produced significant hypertrophy, suggesting the bioavailability or receptor affinity of the IGF-IB isoform diminishes with age