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diet and exercise)

1,961 adults), once-weekly semaglutide produced a mean 14.9% body-weight reduction at 68 weeks versus 2.4% with placebo

Age-related changes in body composition and their sequelae Progressive change in body composition occurs with ageing, characterised by four phenotypes in older adults, that can increase the likelihood of mortality through comorbid disease [11]: sarcopenia, healthy weight, obesity and sarcopenic obesity [12] (Fig

Additionally, the study utilized a single dose regimen without exploring potential doseresponse relationships, and the treatment duration was relatively short (eight weeks), which may not reflect long-term outcomes

This matters because Semaglutide slows gastric emptying and can make meals smaller, which may make it harder to reach daily protein needs without planning