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This is a critical safety boundary to prevent over-medication

Cardiovascular Debate : A 2013 study linked high L-Carnitine intake to increased TMAO (trimethylamine N-oxide) levels, which may raise heart disease risk in some people

For the meta-analysis, different worksheets were created based on the assessed hormone (ghrelin or GLP-1) and effect direction (positive or negative) (Supplementary Material S2)