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Patients who were pregnant, receiving treatment of an active opportunistic infection or malignancy, had vitamin B12 deficiency at screening, or were already taking more than 1 micronutrient supplement pill per day were excluded from the study

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Kovalzon and Strekalova, summarizing the field in 2006, were explicit: the link between DSIP and sleep had never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor, and the hypothesis of DSIP as a sleep factor was extremely poorly documented and still weak (Kovalzon & Strekalova, 2006)

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While antibodies to single-stranded DNA are considered non-specific and often seen in a healthy population, antibodies to double-stranded DNA (dsDNA) are highly specific to lupus diagnosis