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Patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use these medications

Additional studies are necessary to determine which genetic factors underlie susceptibility and the genotypes predisposing to FQAD

While not universal, some patients report that morning dosing allows them to move through early nausea during waking hours when distraction is easier