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The JAHA meta-analysis estimated 25 additional DVT events per 10,000 person-years with GLP-1 agonist use
Notably, despite the dramatic difference in d 3 -TMAO production from oral d 3 -l-carnitine in omnivores versus vegans/vegetarians, the difference observed in the first step of that gut microbiotamediated transformation, conversion of d 3 -l-carnitine to d 3 -BB, was not significant, and if anything showed a trend toward a lower conversion rate in the omnivores ( P = 0.051
Highly fermentable fibers like inulin and fructooligosaccharides can cause significantly more gas and bloating when transit time is already extended
Encouraged healing and repair of damaged tissue
Future generations of incretin agonists may be able to maintain the reduction in blood glucose and body weight while minimizing these off-target effects
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