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Continuing Scientific Uncertainty Later reviews questioned whether the isolated sequence represents a conventional endogenous sleep hormone and whether DSIP-like immunoreactivity may originate from other molecules

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918 , 919 Furthermore, individuals living with Alzheimer's dementia spend an average of 12% of their (individual and spouse/partner) annual income on outofpocket health care services, excluding nursing home and informal care, compared with 7% for individuals without Alzheimer's dementia

It is synthesised in the body, and the extent to which it is a required dietary component under normal circumstances is unclear