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As changes in heat sensitivity are dependent on TRPV1 activity, we sought to determine whether intraplantar injection of 10 g of GLP-1(736) modulates spontaneous pain behavior induced by the TRPV1 agonist CAP in mice
These benefits occur through blood pressure reduction (1-5.4 mmHg lower systolic blood pressure) 10 , improved vascular function, and direct effects on the heart
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
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