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The predicted MM/GBSA binding free energies of the native peptide and designed peptide to the TMD of the IR were 42.68 kcal/mol and 43.59 kcal/mol, respectively, suggesting that ITP binds more tightly to the IR than the native peptide

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Conversely, in chronic treated patients the effects on volume changes are slightly reduced because a new steady state is reached, due to a counter-regulatory effect, resulting in a lower total body sodium concentration and blood volume (53)

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