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Wegovy is typically prescribed with a starting dose of 0.25mg per week, which can be gradually increased to 2.4mg per week

However, PAI-1 carbonylation has been demonstrated to influence its functional activity and structural stability [38], therefore carbonylated PAI-1 may exhibit reduced activity, and we hypothesize that it could trigger a compensatory mechanism leading to an increase in its overall concentration observed in our cohort

de OliveiraMRNabaviSFNabaviSMJardimFR

29 Inconsistent findings in other species (mice) render the generality of these findings unclear