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Limitations of use: - It has not been studied in patients with a history of pancreatitis

This ubiquitous enzyme can cross-link histone, control chromatin condensation, determine gene expression 70 , 71 , affect mitochondrial functions 74 , its activity is affected by creatine kinases and by free creatine 78,79 and its cross-linking activity can impact key essential mitochondrial molecules responsible for energy equilibrium in several autoimmune 81,82,83,84,87,88 and neurodegenerative diseases 79

doi: 10.1002/mc.22777 104 ZhangQLouYZhangJFuQWeiTSunXet al

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