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Although our experience suggests that hydroxocobalamin does not cause clinically significant interference with non-invasive pulse oximetry, there is evidence to suggest that co-oximetric blood gas analysis with several unique analyzers may be altered in the presence of hydroxocobalamin, specifically with false elevations of carboxyhemoglobin and methemoglobin concentrations and underestimation of true oxygen saturation values.5 There is no available evidence regarding the accuracy of other commonly utilized oximetric monitoring modalities (e.g., cerebral oximetry) following hydroxocobalamin administration

The abdomen offers the most surface area for rotation, but the thighs and upper arms also work well

Vegetarians and vegans are at increased risk for vitamin B12 deficiency, since the vitamin mainly comes from animal-based foods (or supplements)

Common reconstitution scenarios clinicians use: 50 mg vial + 2.5 ml water 20 mg/ml - 1 mg = 0.05 ml ( 5 units on a U-100 insulin syringe)

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