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Primary Outcome: Wegovy (2.4 mg) significantly reduced the risk of MACE (a composite of cardiovascular death, non-fatal heart attack, and non-fatal stroke) by 20% compared to placebo when added to standard-of-care cardiovascular therapies over a median follow-up of nearly 40 months

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The concomitant use of alcohol or central nervous system (CNS) depressant drugs (e.g., barbiturates, benzodiazepines, and sleep medications) with phentermine or topiramate may potentiate CNS depression or other centrally mediated effects of these agents