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1 Concurrently, maintaining muscle mass also significantly aids in glucose regulation 34 and promotes a healthier overall metabolic state

However, the tradeoff is a higher risk of under-eating protein, losing lean muscle, and slowing your metabolism

It also promotes satiety by delaying gastric emptying and activating responses in the central nervous system

Both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk (10% and 31%, respectively) as compared with placebo, and an even greater lower risk as compared with DPP-4 inhibitors (15% and 35%, respectively)

Study: GLP-1 receptor agonists for weight reduction in people living with obesity but without diabetes: a living benefitharm modelling study