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GSSG sensitized hepatocytes to TNF-mediated cytotoxicity via the induction of IKK- glutathionylation and subsequent NF-B suppression NF-B activation plays a critical role in protecting hepatocytes from TNF-mediated cytotoxicity

It is known that some of the downstream signal antioxidant enzymes of Nrf2 include SOD, CAT, heme oxygenase-1, glutathione reductase, and glutathione peroxidase 80

For example, individuals who prioritize convenience and adherence may prefer long-acting injectable formulations

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Wu et al., 2024), can effectively deliver drugs to the posterior segment of the eye (Puglia et al., 2021), which is expected to improve the ocular bioavailability and therapeutic efficacy of drugs