tirzepatide not hungry What do you eat when you have no appetite? : r/tirzepatidecompound Why am I still hungry

Ghrelin, the Hunger Hormone: Primarily produced in the stomach, ghrelin signals hunger to the brain

In the ACHIEVE-3 head-to-head against oral semaglutide in T2D, 36 mg orforglipron produced about 9.2% body weight reduction versus about 5.3% on 14 mg oral semaglutide, and superior HbA1c reduction

Whenever youve missed a dose, your body may not handle a higher concentration of the medication well

**Who should consider it:** Patients seeking maximum weight loss, those with type 2 diabetes who need aggressive A1C reduction, and anyone who can tolerate a newer medication with somewhat less long-term data

Some research indicates that blood levels can begin to rise significantly within the first week of daily use