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GLAST and GLT-1 act as Glu transporters in glial cells in vivo and are involved in the regulation of Glu concentration in synaptic clefts, whereas EAAC1 is not involved in the regulation of extracellular Glu levels in synaptic clefts, but rather in the regulation of GSH production via extracellular Cys uptake

When standard glutathione capsules or powders enter the digestive tract, a portion may be degraded before reaching systemic circulation

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doi:10.2215/CJN.0000000584

Time-to-onset (TTO) was defined as the interval (in days) between the start of ICI therapy and the onset of the adverse event