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Combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors could be considered for further metabolic improvements, but newer dual incretin therapies, such as tirzepatide, may be more potent in reducing HbA 1c and body weight [29]

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Researchers believe the mechanism may involve rapid drops in blood sugar, disrupting blood flow to the optic nerve, though this is not yet fully confirmed

They were looking to see if GLP-1 use was linked to a reduced risk of serious mental health outcomesdefined in this study as hospitalization or extended work leave due to mental illness, or death by suicide

Notably, the authors suggested that semaglutide may reduce de novo collagen synthesis without causing degradation of pre-existing collagen fibers [29], implying that semaglutide may not improve existing fibrosis, but it may prevent the initiation and progression of fibrosis, which, however, needs other more focused studies to be definitively demonstrated