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These observations led to an interesting development bifurcation : Melanotan I (Afamelanotide) continued as a skin peptide and in 2014 received approval as Scenesse for erythropoietic protoporphyria (a rare genetic disease with severe photosensitivity) Melanotan II was abandoned as a cutaneous drug PT-141 / Bremelanotide , a fragment of Melanotan II targeted at MC4R, was developed as a sexual stimulant and in 2019 approved as Vyleesi for hypoactive sexual desire disorder in women (HSDD) Second life in research and the cosmetic underground Melanotan II never reached commercial approval as a drug, but in the research community and cosmetic underground it became well known

We are used to doing informed consent for surgery and procedures but not equally good at doing informed consent before prescribing medications

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A 2024 poll from KFF, a nonprofit health policy research, polling and news organization, found that 1 in 8 adults say theyve taken a GLP-1 drug, and over half of adults, 61%, say Medicare should cover the drug for obese Medicare patients

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