GLP-1RAs inhibit RGC apoptosis in glaucoma through GABAergic signaling, but their role in AMD, characterized by oxidative stress and choroidal neovascularization, needs further investigation (Shao et al., 2024)
First, elevated insulin directly suppresses hormone-sensitive lipase, so even if GH rises, lipolysis doesn't increase proportionally
In WT and obese animals, AOD9604 reduces fat mass, increases 3-AR expression, enhances lipolysis, and stimulates energy expenditure and fat oxidation
Opportunities exist in alternative therapeutic areas where there may be more white space for the incretin mimetic class, and these opportunities are garnering the attention of manufacturers (see image 4 below)
Additionally, significant appetite reduction could result in nutritional deficiencies if not managed with a balanced diet