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Melanotan-2 remains the only available pharmacological tool allowing the simultaneous study of the relative contributions of the four MCR receptors using selective antagonism protocols (HS024 for MC4R, JNJ-10229570 for MC3R, etc.)

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Although lifestyle interventionsincluding dietary modifications, exercise, and behavioral changesare the foundational approaches for treating obesity and offer various benefits, even the most rigorous intervention programs achieve only an average weight loss of about 10%

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