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It not only induces breakdown of the existing BBB, but also promotes the growth of structurally altered capillaries (abnormal expression of transporters and receptors) to meet the high metabolic demand of the tumor ( Increased BBB permeability is a hallmark of glioma, in particular in high-grade tumors, such as glioblastomas
Rimi SS, Ashraf MN, Sigma SH, Ahammed MT, Siddique MP, Zinnah MA, et al
This period saw an increase in preclinical studies, investigating BPC 157s effects in animal models of injury, inflammation, and disease
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