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This is important since imbalances in hormone biotransformation are implicated in the initiation of breast cancer through the generation of genotoxic metabolites (i.e., estrogen quinones) and reactive oxygen species (ROS), and the depletion of vital antioxidants and metabolic cofactors 10,11

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Inhibition of p300 by XP-524 has also been reported to increase oncogenic KRAS, which is found to be expressed in 90% of the PDAC cases