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When NRX is oxidized by NADPH oxidase 1 (NOX1)-derived H2O2 or lipid peroxide (ROOH), DVL is released and inhibits glycogen synthesis kinase 3 (GSK3) in the -catenin degradation complex, thereby stabilizing the -catenin in the cytoplasm and partially entering the nucleus to activate the target gene GPX2 by correlation with the TCF/LEF transcription factor family (Figure 2)

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doi: 10.1007/82_2020_196 22 HeS.LiR.PengY.WangZ.HuangJ.MengH.et al

Research suggests methylcobalamin stays in the body longer while cyanocobalamin may be more easily absorbed, but other studies have found little difference in the two in absorption and retention

Primers sequence for beta actin (ACTB), IL-1, FOSL1, CFL1, BMP2 and HSPA1A were synthesized as previously described 24,25,49