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Practical considerations include cost and route of administration, as most formulations are injectable, although oral preparations are emerging

Its development is being led by Eli Lilly and Company, which has progressed the drug into Phase 3 clinical trials following encouraging Phase 2 results

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For PA requests for select high cost, orphan, or accelerated approval drugs without drug-specific clinical criteria, the prescriber is required to complete, sign, and date the PA/DGA form, using Section VII (Clinical Information for Other Drug Requests) of the form

Retatrutide is a triple receptor agonist (GIP, GLP-1, and glucagon) showing even more dramatic weight loss in early trials