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We support continuity of care and we do not position against a treatment you are already using

Armstrong MJ, Hull D, Guo K, et al

For the maintenance treatment of pernicious anemia, the usual dose is 100mcg SC/IM, given once every month

The three libraries were generated using error-prone PCR as described above, using the following conditions to produce varying levels of mutagenesis: Library 1: 2 M 8-oxo-dGTP, 2 M dPTP, 20 PCR cycles Library 2: 4 M 8-oxo-dGTP, 1 M dPTP, 20 PCR cycles Library 3: 8 M 8-oxo-dGTP, 0.5 M dPTP, 20 PCR cycles The library sizes (approximated by number of transformants as described above) were 6 10 7 for each library

Summary of DoseResponse Patterns Both agents demonstrated nonlinear doseresponse relationships, with larger incremental effects at lower doses and attenuation at higher doses