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Globally, diabetes and obesity remain critical health challenges, affecting more than 800 million and 1 billion people, respectively, according to WHO estimates

33 In this respect, its effects parallel those of IGF-1 and IGF-2

Its main actions include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release, which reduces hepatic glucose production Slowing gastric emptying, which moderates post-meal glucose spikes Promoting satiety through central nervous system pathways, thereby reducing appetite GIP is released by K-cells in the proximal small intestine and shares some functions with GLP-1, particularly in enhancing insulin secretion after meals

The most notable concern for long-term use is a potential decrease in zinc levels