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DOI: Published online: April 19, 2021 1 Toronto General Hospital Research Institute, University Health Network, ON, Canada 2 Division of Nephrology, Department of Medicine, University of Toronto, ON, Canada 3 Banting and Best Diabetes Centre, University of Toronto, ON, Canada 4 Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michaels Hospital, ON, Canada 5 Department of Physiology, University of Toronto, Toronto, ON, Canada 6 Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada Corresponding author: David Z.I