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Most patients notice deeper sleep within the first 1 to 2 weeks, faster recovery by weeks 3 to 4, body composition changes by weeks 5 to 8, and skin and energy improvements by weeks 8 to 12

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both have high energy demands due to continuous activitycardiomyocytes for rhythmic contractions and neurons for electrical and chemical signalingand are post-mitotic, making them reliant on mitochondrial quality control as they cannot replace damaged mitochondria through cell division